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Moreover, addition of DEM, a potent thiol-depleting agent, in cell cultures led to I B degradation in TNF- -treated hGH-producing cells (Figure 4D, lower right), while, as expected, a pattern of stabilised I B was shown in U937-hGH cells with an unmodified thiol level (Figure 4D, upper right)

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10.3390/ijms23147986 108 NgoJ

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